WELCOME TO THE KONOPKA LAB

WE ARE A GROUP OF SPIRITED SCIENTISTS EXPLORING THE GENETIC LANDSCAPE OF THE EVOLVED HUMAN BRAIN

Projects


Transcriptional Networks

What are the genes and pathways disrupted in neurodevelopmental disorders such as autism? We are using a combination of computational and wet-bench approaches to elucidate novel signal cascades important for the pathophysiology of autism. We are focused on identifying the neural circuits and cell-type contributions of these genes to brain development. We are also developing new rodent models for testing the behavioral consequences of modifying these genes.

Evolution of Human Cognition

What are the human-specific gene expression signatures and signaling pathways? We are taking a comparative genomics approach to identify genes that have been modified in the human brain. Genes of interest are being further examined using both human neuronal cultures and animal models.

Cognitive Genomics

Which genes are important for human cognition from a functional standpoint? We are examining the correspondence of human brain gene expression with measurements of human brain activity. We are also examining how these correlations are disrupted in cognitive disorders.

Lab Members



Principal Investigator


Postdoctoral Fellow


Postdoctoral Fellow


Postdoctoral Fellow


Postdoctoral Fellow


Neuroscience
Graduate Student


Neuroscience
Graduate Student


Neuroscience
Graduate Student


Neuroscience
Graduate Student


Neuroscience
PhD Student


UTD Green Fellow
Undergraduate Researcher


Research Assistant


Research Assistant

Publications


Featured Publication


Insights into the neural and genetic basis of speech

The neuronal circuits implicated in learning and accurately producing vocalizations include several interconnected networks in the cortex, basal ganglia, and cerebellum. While less is known about the gene networks involved in vocal communication, genetic screens of individuals with inherited speech disorders and the continued biological examination of neuronal circuits in vocal learning species, like songbirds, provide insights into the brain and genetic mechanisms for vocal communication.

All Publications

Hanners NW, Eitson JL, Usui N, Richardson RB, Wexler EM, Konopka G, Schoggins JW (2016) Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects. Volume 15, Issue 11, 14 June 2016, Pages 2315–2322. Link

Berto, S., Usui, N., Konopka, G.*, and Fogel, B.L.* (2016) ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism. In press, Human Molecular Genetics. *Co-corresponding author.

Konopka, G., and Roberts, T.F. (2016) Insights into the neural and genetic basis of speech. Cell164(6):1269-76.

Konopka, G., and Roberts, T.F. (2016) Animal models of speech and vocal communication deficits associated with psychiatric disorders. Biological Psychiatry 79(1):53-61.a.

Usui, N., Co, M., Harper, M., Reiger, M.A., Dougherty, J.D., and Konopka, G. (2016) Sumoylation of FOXP2 regulates motor function and vocal communication through Purkinje cell development. In press, Biological Psychiatry, online Feb 12, doi 10.1016/j.biopsych.2016.02.008.

Wang G.-Z.*, Belgard, T. G.*, Mao, D., Chen, L., Berto, S., Preuss, T. M., Lu, H., Geschwind, D. H.,Konopka, G. Correspondence between Resting-State Activity and Brain Gene Expression.Neuron. 2015, 88 (4): 659–666.* Equal Contribution.

Wang G.-Z., Hickey S. L., Shi L., Huang HC., Nakashe P., Koike N., Tu B.P., Takahashi JS., Konopka G. Cycling Transcriptional Networks Optimize Energy Utilization on a Genome Scale. Cell Reports.2015, 13(9): 1868–1880.

Araujo, D.J.*, Anderson, A.G.*, Berto, S., Runnels, W., Harper, M., Ammanuel, S., Rieger, M.A., Huang, H-C., Rajkovich, K., Loerwald, K.W., Dekker, J.D., Tucker, H.O., Dougherty, J.D., Gibson, J.R., and Konopka, G. (2015) FoxP1 orchestration of ASD-relevant signaling pathways in the striatum. Genes & Development 29(20): 2081-96. *Equal Contribution.

Frank, E., Benabou, M., Bentzley, B., Bianchi, M., Goldstein, T., Konopka, G, Maywood, E., Pritchett, D., Sheaves, B., Thomas, J. (2014) Influencing circadian and sleep-wake regulation for prevention and intervention in mood and anxiety disorders: what makes a good homeostat? Ann N Y Acad Sci1334:1-25.

Usui, N., Co, M., and Konopka, G. (2014) Decoding the molecular evolution of cognition using comparative genomics. Brain, Behavior, and Evolution 84(2):103-16.

Fontenot, M., and Konopka, G. (2014) Molecular networks and evolution of human cognitive skills. Current Opinion in Genetics & Development 29C:52-59.

Lepp, S., Anderson, A., and Konopka, G. (2013) Connecting signaling pathways underlying communication to ASD vulnerability, in International Review of Neurobiology: Neurobiology of Autism (ed G. Konopka), Elsevier; 113:97-133.

Miller, D.J., and Konopka, G. (2013) Evolution and Development of Language, in Advances in Evolutionary Developmental Biology (ed J.T. Streelman), John Wiley & Sons, Inc, Hoboken, NJ, USA; 173-201.

Wang, G-Z., and Konopka, G. (2013) Decoding human gene expression signatures in the brain.Transcription 4(3):1-7.

Konopka, G. (2013) FOXP2: linking language and autism, in The Autisms: Molecules to Model Systems (eds. C.M. Powell, C.M. and L.M. Monteggia), Oxford University Press, New York, NY, USA; 367-393.

Bowers, J. M., and Konopka, G. (2012) ASD-relevant animal models of the Foxp family of transcription factors. Autism Open Access S1:010. http://www.omicsgroup.org/journals/2165-7890/2165-7890-S1-010.php?aid=10082

Bowers, JM, and Konopka, G. (2012) The role of the FOXP family of transcription factors in ASD. Dis Markers 33(5):251-60.

Konopka, G., Friedrich, T., Davis-Turak, J., Winden, K., Oldham, M.C., Gao, F., Chen, L., Wang, G-Z., Luo, R., Preuss, T.M., and Geschwind, D.H. (2012) Human-specific transcriptional networks in the brain. Neuron 75(4):601-617.

Wang, G-Z., and Konopka, G. (2012) Differential Functional Constraints on the Evolution of Postsynaptic Density Proteins in Neocortical Laminae. PLOS One 7(6): e39686.

Geschwind, D.H., and Konopka, G. (2012) Neuroscience: genes and human brain evolution. Nature486(7404):481-2.

Konopka, G. (2012) The fetal brain provides a raison d’etre for the evolution of new human genes.Brain Behav Evol 79(4):213-4.

Gena's Other Research

Fogel, B.L., Cho, E., Wahnich, A., Gao, F., Becherel, O.J., Wang, X., Fike, F., Chen, L., Criscuolo, C., De Michele, G., Filla, A., Collins, A., Hahn, A.F., Gatti, R.A., Konopka, G, Perlman, S., Lavin, M.F., Geschwind, D.H., and Coppola, G. (2014) Mutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2. Hum Mol GenetEpub Apr 23.

Zeng, J, Konopka, G, Hunt, BG, Preuss, TM, Geschwind, D, Yi, SV. (2012) Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution. Am J Hum Genet. 91(3):455-65.

Fogel, B.L., Wexler, E., Wahnich, A., Friedrich, T., Vijayendran, C., Gao, F., Parikshak, N., Konopka, G., and Geschwind, D.H. (2012) RBFOX1 regulates both splicing and transcriptional networks in human neuronal development. Hum Mol Genet 21(19):4171-86.

Puram, S.V., Yeung, C.M., Jahani-Asl, A., Lin, C., de la Iglesia, N., Konopka, G., Jackson-Grusby, L., and Bonni, A. (2012) STAT3-iNOS signaling mediates EGFRvIII-induced glial proliferation and transformation. Journal of Neuroscience 32(23):7806-18.

DeLaForest, A., Nagaoka, M., Si-Tayeb, K., Noto, F.K., Konopka, G., Battle, M.A., and Duncan, S.A. (2011) HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells. Development 138(19):4143-53.

Mukamel, Z.*, Konopka, G.*, Wexler, E., Dong, H., Osborn, G., Levitt, P., and Geschwind, D.H. (2011) Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism risk. Journal of Neuroscience 31(32):11437-42. *Equal Contribution.

Konopka, G., Wexler, E., Rosen, E., Mukamel, Z., Osborn, G. E., Chen, L., Lu, D., Gao, F., Gao, K., Lowe, J.K., and Geschwind D. H. (2012) Modeling the functional genomics of autism using human neurons. Molecular Psychiatry 17(2):202-14.

Konopka, G. (2010) Functional genomics of the brain: uncovering networks in the CNS using a systems approach. WIREs Systems Biology and Medicine, Epub Dec 31.

Konopka, G., and Geschwind, D.H. (2010) Human brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior. Neuron 68(2):231-44.

Konopka, G., Bomar, J.M., Winden, K., Coppola, G., Jonsson, Z.O., Gao, F., Peng, S., Preuss, T.M., Wohlschlegel, J.A., and Geschwind, D.H. (2009) Human-specific transcriptional regulation of CNS development genes by FOXP2. Nature 462 (7270):213-7.

Geschwind, D.H. and Konopka, G. (2009) Neuroscience in the era of functional genomics and systems biology. Nature 461(7266):908-15.

Oldham, M.C., Konopka, G., Iwamoto, K., Langfelder, P., Kato, T., Horvath, S., and Geschwind, D. H. (2008) Functional organization of the transcriptome in human brain. Nature Neuroscience11(11):1271-82.

de la Iglesia, N.*, Konopka, G.*, Nutt, C.L., Bromberg, J.F., Frank, D.A., Mischel, P.S., Louis, D.N., and Bonni, A. (2008) Deregulation of a STAT3-IL8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. Journal of Neuroscience 28(23):5870-8. *Equal contribution.

de la Iglesia, N.*, Konopka, G.*, Puram, S., Chan, J.A., Bachoo, R.M., You, J.M., Levy, D.E., DePinho, R.A., and Bonni, A. (2008) Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes and Development 22(4):449-62. * Equal contribution.

Spiteri, E., Konopka, G., Coppola, G., Bomar, J., Oldham, M., Ou, J., Vernes, S.C., Fisher, S.E., Ren, B., and Geschwind, D.H. (2007) Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. American Journal of Human Genetics81(6): 1144-57.

Konopka, G., Tekiela, J., Iverson, M., Wells, C., Duncan, S.A. (2007) Junctional adhesion molecule-A is critical for the formation of pseudocanaliculi and modulates E-cadherin expression in hepatic cells. Journal of Biological Chemistry 282(38): 28137-48.

Keeping up with the Konopka Lab

March 2017: Miles passed his dissertation defense entitled "The Evolution and Function of the Genomic Landscape of the Human Brain"! Congrats and good luck!

March 2017: Welcome to our new post-docs Fatma and Yuxiang!

March 2017: Our rotation student Emily joins the lab! Welcome Emily!

January 2017: Connor joins the lab! Welcome Connor!

November 2016: Marissa wins a Keystone Symposia Travel Award! Congrats!

September 2016: Konopka Lab wins the golden brain in the 2016 Summer Lab Olympics! Congrats to Team Dragon-Thunder!

August 2016: Aarin finishes her rotation in the Konopka Lab- good luck with your future studies!

August 2016: The new lab website goes live! Thanks for checking it out!

June 2016: STAR Student Yosiah joins the lab for the summer! Welcome!

May 2016: Nori teams up with members of the Schoggins lab to publish a study on Zika virus in Human Neural Progenitors in Cell Reports!

April 2016: Stefano's paper, "ELAVL2-regulated transcriptional and splicing networks in human neurons link neurodevelopment and autism", is accepted at Human molecular genetics. Congrats Stefano!

Former Lab Members


Dan Miller

Visiting Scientist

(May-Jul 2011)

Regan Allen

Summer Intern

(Jun-Aug 2012)

Lupita Rios

STARS Fellow

(Jun-Jul 2012)

Christine Ochoa

Rotation student

(Oct-Dec 2012)

Maria Funes

Research assistant

(Sep 2011-Sep 2012)

Mike Bowers, Ph.D.

Postdoctoral Fellow

(Jan 2012-Mar 2013)

Julia Mandel

Student Intern

(Jun 2012-Mar 2013)

Steven Wen Qi, M.S.

Bioinformatics

(Jan-Jul 2013)

Emma Konopka

Summer Intern

(Jul-Aug 2013)

Dean Itani

SURF Fellow

(Jun-Aug 2012, Jun-Aug 2013)

Rodney Chen

Summer Intern

(Jun-Aug 2013)

Wesley Runnels

STARS Student

(Jun 2013-Aug 2014)

Taylor Stefanik

SURF Fellow

(Jun 2014-Aug 2014)

Jayant Madugula

STARS Student

(Jun 2014-Jul 2015)

Chandler Werthmann

SURF Fellow

(Jun-Aug 2015)

Enrique De Alba

STARS Student

(Jun-Aug 2015)

Hanqing (Kathy) Shang

Undergraduate Intern

(Oct 2015-Jan 2016)

Guang-Zhong Wang, Ph.D.

Postdoctoral Fellow

(Aug 2011-Mar 2016)

Kazuya Toriumi, Ph.D.

Post-Doc

(Mar 2015- Mar 2017)

Noriyoshi Usui, Ph.D.

Post-Doc

(Oct 2012- Mar 2017)

Miles Fontenot, Ph.D.

MD/PhD Neuroscience Graduate Student

(Jul 2013-Mar 2017)

Get in touch


Konopka lab
Department of Neuroscience
UT Southwestern Medical Center
5323 Harry Hines Blvd., ND4.300
Dallas, TX 75390-9111
Ph: 214-648-5135 (Office), 214-648-5136 (Lab)
Email
Genevieve.Konopka[at]UTSouthwestern[dot]edu